Impacto do uso sistêmico de estatinas e de bisfosfonatos nos tecidos periodontais: revisão narrativa / Impact of the systemic use of statins and bisphosphonates in the periodontal tissues: narrative review

Introdução: A literatura tem apontado uma possível relação entre diversas condições sistêmicas e as doenças periodontais. Dentro das doenças sistêmicas que podem gerar o uso crônico de medicamentos, com potencial associação com as doenças periodontais, destacam-se a hipercolesterolemia e o uso de estatinas; e as doenças do metabolismo ósseo e o uso de bisfosfonatos. Objetivo: Dessa maneira, o presente estudo objetivou revisar a literatura sobre o efeito das estatinas e dos bisfosfonatos nos parâmetros clínicos e radiográficos periodontais de indivíduos adultos. Resultados: Apenas estudos observacionais em humanos foram incluídos. Um estudo mostrou que, em pacientes que apresentam doença periodontal e usam estatina, houve 37% menos bolsas periodontais (profundidade de sondagem ≥4mm) quando comparadas aos que não utilizam a medicação, além de apresentarem menor índice de carga inflamatória e menor perda de inserção clínica. Em relação aos bisfosfonatos em indivíduos com doenças que envolvem o metabolismo ósseo, sugere-se que a utilização do fármaco tem obtido resultados positivos nos parâmetros periodontais, como menores sinais clínicos de inflamação gengival, menor profundidade de sondagem, menor perda de inserção clínica e maior nível de osso alveolar, quando comparados aos que nunca realizam essa terapia. Conclusão: Dessa forma, as estatinas e os bisfosfonatos apresentam efeitos promissores, em pacientes sob tratamento para suas respectivas condições sistêmicas, na melhoria dos parâmetros periodontais, porém é importante salientar que são necessários mais estudos sobre o assunto para melhor entender os reais efeitos a longo prazo do uso desses fármacos.(AU)

Introduction: The literature showed a possible relationship between several systemic conditions and periodontal diseases. Within the systemic diseases that can generate the chronic use of these drugs, potentially related with periodontal diseases, it may be cited the hypercholesterolemia and the use of statins; and bone metabolism diseases and the use of bisphosphonates. Objective: In this sense, the present study aimed to review the literature about the effect of statins and bisphosphonates in the periodontal parameters of adults individuals. Results: Only observational studies in humans were included. A study showed that, in patients with periodontal disease and users of statins, there 37% fewer periodontal pockets (probing depth ≥4mm) when compared to those who do not use the medication, as well as having a lower rate of inflammatory burden and less loss of clinical insertion. Regarding the bisphosphonates in individuals diagnosed with diseases involving bone metabolism, it was suggested that the use of the drug has obtained positive results in periodontal parameters, such as a greater absence of plaque, less clinical signs of gingival inflammation, less probing depth, lower level of clinical insertion and higher level of alveolar bone when compared to those who never undergo this therapy. Conclusion: Thus, statins and bisphosphonates have promising effects in patients under treatment for their respective systemic condition in improving periodontal parameters, but it is important to emphasize that further studies on the subject are needed to better understand the long-term effects of the use of these drugs.(AU)

Tratamento de periodontite estágio III localizado grau C em um indivíduo fumante: um relato de caso / Treatment of periodontitis stage III localized grade C in smoker individual: a case report

Objetivo: A periodontite é uma doença infecto-inflamatória que acomete os tecidos de inserção periodontal, e ser fumante representa um risco modificável significativo para todos os graus da doença. Ainda, indivíduos fumantes apresentam uma resposta inflamatória alterada quando comparados a não fumantes. Nesse contexto, o objetivo deste estudo foi reportar um relato de caso de tratamento periodontal de paciente fumante pesado. Relato de caso: O paciente DRS, sexo masculino, 22 anos, foi encaminhado à Faculdade de Odontologia da Universidade Federal de Pelotas (UFPel) com a queixa principal de necessidade de "realização de uma limpeza dentária". Na anamnese, relatou fumar 20 cigarros ao dia, há 7 anos (7 maços-ano). Na consulta inicial, foi encontrado índice de placa visível (IPV) de 100% e índice de sangramento gengival (ISG) de 66,67%. Foi encontrado cálculo supragengival como fator retentivo de placa (FRP) em 46,30% dos sítios. Estabeleceu-se o diagnóstico de periodontite estágio III localizado grau C. Os exames periodontais foram realizados por um único pesquisador calibrado e optou-se pelo tratamento periodontal não cirúrgico. Ao exame de 12 meses, o paciente apresentou IPV de 23,45% e ISG de 22,83%. Houve ausência de FRP. De uma forma geral, foi possível constatar a diminuição significativa das bolsas periodontais, bem como o ganho significativo de inserção clínica periodontal. Considerações finais: Dessa forma, é possível concluir a efetividade da terapia periodontal não cirúrgica, aliada à manutenção periodontal e instruções de higiene para o tratamento de periodontite estágio III, grau C, em paciente fumante.(AU)

Objective: Periodontitis is an infect-inflammatory diseases that affects the periodontal attachment tissues, and being smoker represents a significant modifiable risk for all degrees of the disease. Moreover, smokers have an altered inflammatory response when compared to non-smokers. Therefore, the aim of this study was to report a case report of periodontal treatment of a heavy smoker. Case report: A patient DRS, male, 22 years old, was referred to the School of Dentistry of the Federal University of Pelotas (UFPel) with the main complaint of the need to "perform a dental cleaning". During the anamnesis, he reported smoking 20 cigarettes a day for 7 years (7 pack-years). In the initial appointment, a visible plaque index (VPI) of 100% and a gingival bleeding index (GBI) of 66.67% were found. Supragingival calculus was found as a plaque retentive factor (PRF) in 46.30% of the sites. The diagnosis of periodontitis stage III localized grade C was established. Periodontal examinations were performed by a single calibrated researcher and non-surgical periodontal treatment was chosen. At the 12-month appointment, the patient had an VPI of 23.45% and an GBI of 22.83%. There was absence of PRF. In general, it was possible to observe a significant decrease in periodontal pockets, as well as a significant gain in periodontal clinical attachment. Final considerations: Thus, it is possible to conclude the effectiveness of non-surgical periodontal therapy, combined with periodontal maintenance and hygiene instructions for the treatment of periodontitis stage III localized grade C in a smoker.(AU)

Association between dental environment stress and sense of coherence in dental students: a cross-sectional study

Abstract The aim of this study was to explore associated variables with sense of coherence (SOC), and dental environment stress (DES) in a sample of dental students. All undergraduate (n = 474) and graduate (n = 105) dental students enrolled in the first semester of 2020 at a public university in southern Brazil were invited to participate. Data collection was performed by an online questionnaire, which included information related to sociodemographic and educational characteristics, biopsychosocial factors, aspects related to feelings experienced in the COVID-19 pandemic, and the SOC scale. The study outcome (DES) was measured by a validated tool. Linear regression analyses were performed to identify the associations between the outcome and all independent variables. A total of 408 students were included (response rate: 70.5%). The overall mean score of the DES scale was 73.95 (SD: 24.13). Students with higher SOC scores were observed to have significantly lower DES scores (βGRADUATE: -0.376; 95%: -0.482 to -0.271; βUNDERGRADUATE: -0.478; 95%:-0.658 to -0.297). Female undergraduate students (β: 11.788; 95%CI: 7.161-16.415) had higher DES scores compared with undergraduate male students. In addition, the presence of anxiety symptoms when providing dental care to patients with symptoms or suspected COVID-19 infection was associated with higher DES scores (β: 10.460; 95%CI: 5.644-15.277) among undergraduate dental students. The level of stress was higher in non-white undergraduate students than white (β: 8.912; 95%CI: 3.581-14.244). Among both undergraduate and graduate dental students, higher SOC scores were associated with lower DES.

Prevalence of depressive symptoms among dental students is influenced by sex, academic performance, smoking exposure, and sexual orientation: cross-sectional study

Aim: To estimate the prevalence and associated factors of self-reported depressive symptoms in undergraduate and graduate dental students. Methods: The Depression, Anxiety and Stress Scale (DASS-21) was applied, and only the depression domain was verified. A structured questionnaire was used to collect sociodemographic, behavioral, and COVID-19 pandemic-related fear variables. Academic performance was assessed based on academic records, ranging from 0 (worst possible grade) to 10 (best possible grade). Respondents included 408 regularly enrolled dental students. Bi- and multivariate analyses were performed using Poisson regression with robust variance to verify the association between at least moderate depressive symptoms and independent variables. Results: The prevalence of at least moderate depression was 40.5% among undergraduate students and 26% among graduate students. The prevalence of fear and anxiety due to the COVID-19 pandemic was 96.1% among undergraduate students and 93.5% among graduate students. In the final multivariate analysis, being female (prevalence ratio [PR]:2.01; 95% confidence interval [95%CI]:1.36­2.96) was associated with a higher PR for depression. Conversely, no exposure to smoking (PR:0.54; 95%CI:0.36­0.82) and a final academic performance average ≥7.0 (PR:0.56; 95%CI:0.41­0.76) was associated with a lower PR for depression. Finally, among graduate students, a non-heterosexual orientation was associated with a higher PR for depression (PR:6.70; 95%CI:2.21­20.29). Conclusion: Higher rates of depression symptoms were observed in female undergraduates, students with lower academic performance and smoking exposure, and graduate dental students with a non-heterosexual orientation

Higher maternal age is associated with higher occurrence of cleft lip/palate in neonates under intensive care

Aim: To assess the prevalence of cleft lip and/or cleft palate (CL/P) and associated variables in neonates admitted to neonatal intensive care units (ICU). Methods: Medical charts for neonates born and admitted to the ICU between 2012 and 2018 were reviewed. Obstetric and neonatal variables were collected by a trained researcher. In the case group, all neonates with CL/P were included. The control group was formed by matching sex, prematurity and month of birth using random number generation. Neonates with congenital malformations were excluded from the control group. Adjusted logistic regression was used (p<0.05). Results: The prevalence of CL/P was 0.43% (n=15). Five cases were excluded, as pairing was not possible. Twenty neonates were included in the control group. In the final multivariate model, CL/P was only associated with increased maternal age. For each year of increase in maternal age, neonates had a 35.2% higher chance of presenting CL/P (95% confidence interval: 1.021­1.792). Conclusions: Higher maternal age was associated with higher occurrence of CL/P in neonates admitted to the ICU. No other neonatal or maternal independent variables were associated with CL/P. Due to missing data, interpretation of study results must be approached with caution

Edentulism and number of medications are associated with nutritional status in older adults: a population-based cross-sectional study / Edentuslimo e número de medicações estão associados com estado nutricional em idosos: um estudo transversal de base populacional

ABSTRACT Objective: This study evaluated the nutritional status and associated factors among older adults of a southern Brazilian city. Methods: A cross-sectional home-based study, with a probabilistic sample per cluster, was carried out with 282 older adults aged ≥60 years in the city of Veranópolis, Brazil. Through a structured questionnaire, socioeconomic, general and behavioral health aspects were assessed. Nutritional status was assessed using the Mini Nutritional Assessment (MAN®) instrument, categorizing the sample into eutrophic or nutritional risk (risk of malnutrition + malnourished). Oral health was assessed by counting teeth and the use of and need for dental prosthesis. Two independent multivariate models were constructed, using number of daily medication and polypharmacy (≥2 daily medications). Logistic regression was used to verify associations. Results: The prevalence of nutritional risk was 14.5% (N=41). In the final multivariate analysis, users of ≥6 daily medications demonstrated a greater odds ratio (OR) of being at nutritional risk when compared to those who did not use medication daily (OR: 12.16; 95% confidence interval [95%CI]: 1.47 - 100.82). Non-edentulous older adults had 67.7% (p = 0.006) lower OR for nutritional risk when compared to edentulous. Conclusion: The prevalence of nutritional risk was low among this sample, and it was associated with edentulism and number of daily medications.

RESUMO Objetivo: Esse estudo avaliou o estado nutricional e fatores associados em idosos de uma cidade do Sul do Brasil. Métodos: Um estudo transversal de base populacional, com amostragem probabilística por cluster, foi realizado com 282 idosos com idade ≥60 anos na cidade de Veranópolis, Brasil. Por meio de um questionário estruturado, aspectos socioeconômicos, comportamentais e de saúde geral foram aferidos. Estado nutricional foi verificado usando a Mini Avaliação Nutricional (MAN), categorizando a amostra em eutróficos e risco nutricional (risco de desnutrição + desnutridos). Saúde bucal foi verificada pela contagem dos dentes e uso e necessidade de prótese dentária. Dois modelos multivariados independentes foram construídos, utilizando o número de medicações diárias e polifarmácia (≥2 medicamentos por dia). Regressão logística foi utilizada para verificar as associações. Resultados: A prevalência de risco nutricional foi de 14,5% (N=41). Na análise multivariada final, usuários de ≥6 medicamentos por dia demonstraram uma maior razão de chance (RC) de terem risco nutricional quando comparados com aqueles que não utilizaram medicamento diariamente (RC: 12,164; intervalo de confiança de 95% [IC95%]: 1,468 - 100,821). Idosos não edêntulos tiveram 67,7% (p=0,006) menor RC para risco nutricional quando comparados com não edêntulos. Conclusão: A prevalência de risco nutricional foi baixa nessa amostral, ela foi associada com edentulismo e número diário de medicações.

A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures

Aim: This study aimed to systematically review existing literature regarding the association between dental procedures­such as tooth extractions and periodontal therapy­and occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs. Methods: Search strategies were performed in PubMed, Scopus, Web of Science and Cochrane Library for a timeframe ending in December 2021. Study selection, data extraction and risk of bias were analyzed independently by two researchers. Three meta-analyses were performed, estimating the crude risk ratio (RR), the adjusted odds ratio (OR) and the adjusted hazard ratio (HR) for the association between tooth extraction and MRONJ. Results: Of the 1,654 studies initially retrieved, 17 were ultimately included. The majority of patients with MRONJ in these studies were female, with a mean age of 64 years. Zoledronic acid was the most commonly used drug among patients with MRONJ, and cancer was the most frequent underlying health condition. Regarding the performed meta-analyses, crude and adjusted analyses demonstrated that tooth extraction increased the risk for MRONJ by 4.28 (95% confidence interval [95%CI]: 1.73­10.58), the OR for MRONJ by 26.94 (95%CI: 4.17­174.17), and the HR for MRONJ by 9.96 (95%CI: 4.04­24.55). Conclusion: It was concluded that performing dental procedures, especially tooth extraction, in patients using bone-modifying drugs increased the risk of MRONJ occurrence and, therefore, should be avoided. Further studies, using adjusted data, are warranted

Female and Worst Academic Performance are Associated with Anxiety and Stress among Dental Students / Mulheres e Pior Desempenho Acadêmico Estão Associados com Ansiedade e Estresse em Estudantes de Odontologia

This study aimed to assess the levels and associated factors of stress and anxiety in dental students during the Covid-19 pandemic. This cross-sectional study involved both undergraduate and graduate dental students regularly enrolled in the first semester of 2020 of one University. An online structured questionnaire was applied, and demographical, behavioral, academic performance, fear and anxiety related to the Covid-19 pandemic were collected. The 21-item Depression Anxiety Stress Scale (DASS-21) was applied, but only the subscales of anxiety and stress were considered. Adjusted analyses were performed using Poisson regression with robust variance. To both anxiety and stress, independent analyses were performed considering the different levels of study (undergraduate and graduate dental students). At least moderate anxiety was detected in 42.9% and 24.7% of undergraduate and graduate students, respectively. Meanwhile, at least moderate stress was observed in 41.7% and 29.9% of undergraduate and graduate students, respectively. In the multivariate analyses, female undergraduate dental students presented significantly more anxiety (prevalence ratio [PR]: 1.57; 95% confidence interval [95%CI]: 1.11 ­ 2.22) and stress (PR: 1.54; 95%CI: 1.06 ­ 2.24) when compared to males. Conversely, undergraduate dental students with better academic performance demonstrated lower rates of anxiety (PR: 0.86; 95%CI: 0.75 ­ 0.98). Females undergraduate dental students demonstrate higher rates of anxiety and stress, and the academic performance may influence the levels of anxiety in these individuals. (AU)

O estudo objetivou avaliar os níveis e fatores associados de estresse e ansiedade em estudantes de Odontologia durante a pandemia de Covid-19. Esse estudo transversal envolveu alunos de graduação e pós-graduação em Odontologia regularmente matriculados no primeiro semestre de 2020 de uma Universidade. Um questionário estruturado online foi aplicado, e variáveis demográficas, comportamentais, performance acadêmica, medo e ansiedade relacionados à pandemia de Covid-19 foram coletadas. A "Depression Anxiety Stress Scale" (DASS-21) de 21 itens foi aplicada, mas somente os domínios de ansiedade estresse foram considerados. Análises ajustadas foram realizadas utilizando regressão de Poisson com variância robusta. Para ambos ansiedade e estresse, análises independentes foram realizadas considerando os diferentes níveis de estudo (estudantes de odontologia de graduação e pós-graduação). Pelo menos ansiedade moderada foi detectada em 42,9% e 24,7% dos alunos de graduação e pós-graduação, respectivamente. Já o estresse pelo menos moderado foi observado em 41,7% e 29,9% dos alunos de graduação e pós-graduação, respectivamente. Nas análises multivariadas, mulheres estudantes de graduação apresentaram significativamente mais ansiedade (razão de prevalência [RP]: 1,57; intervalo de confiança de 95% [IC95%]: 1,11 ­ 2,22) e maior estresse (RP: 1,54; IC95%: 1,06 ­ 2,24) quando comparados com homens. Contudo, estudantes de graduação com melhor performance acadêmica demonstraram menores taxas de ansiedade (RP: 0,86; IC95%: 0,75 ­ 0,98). Estudantes de graduação do sexo feminino demonstraram maiores taxas de ansiedade e estresse, e a performance acadêmica pode influenciar os níveis de ansiedade desses indivíduos. (AU)

Use and need of dental prosthesis among community dwelling elderly: a cross-sectional population-based study / Uso e necessidade de próteses dentárias em idosos domiciliados: um estudo transversal de base populacional

Abstract Background By the use of complete or partial dental prosthesis, function, esthetics, and phonetics are reestablished. Few population-based studies are available in the literature using an older adult population. Objective Evaluate the use of and need for dental prostheses and their associated factors. Method This study included a random sample of 287 elderly, in the city of Cruz Alta, Brazil. Use of and need for dental prostheses were the main outcomes, and two analytical models were constructed. Subgroup analyses were performed for individuals using fixed partial denture (FPD) and removable (partial and/or complete) dental prosthesis (RDP). Results Use of and need for dental prosthesis were identified in 83.6% (n=240) and 42.5% (n=122) of the elderly, respectively. Women presented a significantly higher prevalence ratio (PR) for use of dental prostheses (PR=1.15; 95%IC:1.02-1.28) and lower need (PR=0.70; 95%IC:0.54-0.91). No statistically significant difference was demonstrated for the use of FPD regarding the sex. Higher education level was associated with lower use of prostheses (PR=0.73; 95%IC:0.58-0.91) when compared to lower level of education. Medium level of education showed a significantly lower need for dental prostheses (PR=0.61 - 95%IC:0.39-0.94). Those that did not consume alcohol presented with a significantly lower use of FPD and RDP (PR=0.46; 95%IC:0.23-0.93 and 0.90;0.81-0.99, respectively). Conclusion The use of and need for dental prostheses were associated with sex, level of education, and behavioral factors.

Resumo Introdução Pelo uso de próteses dentárias completas ou parciais, função, estética e fonética são reestabelecidas. Poucos estudos de base população estão disponíveis na literatura utilizando a população idosa. Objetivo Avaliar o uso e a necessidade de prótese dentária, bem como seus fatores associados. Método Esse estudo incluiu uma amostra randômica de 287 idosos da cidade de Cruz Alta, no Brasil. Uso e necessidade de prótese dentária foram os desfechos primários, e dois modelos analíticos foram construídos. No uso de prótese dentária, análises de subgrupos foram realizadas para Prótese Parcial Fixa (PPF) e Prótese Removível (parcial e/ou completa) (PR). Resultados Uso e necessidade de prótese dentária foram detectados em 83,6% (n=240) e 42,5% (n=122) dos idosos, respectivamente. Mulheres apresentaram significativa maior Razão de Prevalência (RP) para o uso de prótese dentária (RP:1,15; IC95%:1,02-1,28) e menor necessidade (RP:0,70; IC95%:0,54-0,91). Nenhuma associação significativa foi encontrada para o uso de PPF em relação aos gêneros. Alto nível educacional esteve associado ao menor uso de prótese (RP:0,73; IC95%:0,58-0,91), quando comparado com escolaridade baixa. Escolaridade média mostrou significativa menor necessidade de prótese dentária (RP:0,61 - IC95%:0,39-0,94). Aqueles que não utilizam álcool apresentaram um menor uso de PPF e PR (RP:0,46; IC95%:0,23-0,93 e 0,90;0,81-0,99, respectivamente). Conclusão Uso e necessidade de prótese dentária estão associados ao gênero, nível educacional e fatores comportamentais.

Antimicrobial potential of essential oils mouthrinses with and without alcohol: a randomized clinical trial

Aim: This study aimed to compare the microbiological potential and gustatory perception of essential oils (EO) mouthrinses containing and not containing alcohol. Methods: Twenty healthy adult volunteers rinsed with 10mL of the following test solutions: EO with alcohol, EO without alcohol, or a control solution (saline solution with mint essence). A washout period of at least seven days was adopted after a single-use protocol of the respective solution. All participants used all three tested substances. Antimicrobial potential was assessed by counting salivary total viable bacteria both before and after each rinse. Gustatory perception was evaluated using the Visual Analogue Scale (VAS). Multiple comparisons were performed with the Wilcoxon test, using Bonferroni correction. Results: Both EO solutions presented a higher antimicrobial potential in comparison to the control solution (p<0.017). However, no significant difference in antimicrobial potential was observed between EO containing or not containing alcohol (p=0.218). VAS of EO with alcohol (median: 2.7) was similar to control solution (median: 1.6) (p=0.287). A better gustatory perception was observed of the EO without alcohol (median 7.6) when compared to the control solution (p<0.0001). When EO groups were compared, EO without alcohol also demonstrated a significantly better gustatory perception (p=0.001). Conclusion: Mouthrinse containing EO without alcohol presented a better taste perception when compared to the EO with alcohol, but no difference was observed in the antimicrobial potential of both EO solutions after a single rinse protocol

Prevalence of temporomandibular disorder and possible associated factors in a sample of older adults: population-based cross-sectional study / Prevalência de disfunção temporomandibular e possíveis fatores associados em uma população de idosos: estudo transversal de base populacional

ABSTRACT BACKGROUND AND OBJECTIVES: Temporomandibular disorders (TMD) are a group of conditions characterized by changes in the movements and function of the orofacial region and one of main reported symptoms is pain. As it has been increasingly described among different age groups, this study aimed to evaluate the presence of symptoms of TMD and their possible associated factors in older people from a city in southern Brazil. METHODS: A cross-sectional household-based study using a per cluster sampling strategy was performed including 282 older adults aged ≥60 years in the city of Veranópolis/RS. A clinical oral examination and a structured questionnaire were applied. TMD symptoms were evaluated with Fonseca Anamnestic Index (FAI) questionnaire and divided into those "without TMD" and "with TMD" (the later including those reporting mild, moderate and severe TMD symptoms). Associations were performed by the chi-square or Mann-Whitney tests based on frequency distribution. Bi and multivariate analyses were performed using Poisson regression with robust variation to verify associations. RESULTS: Prevalence among older adults that reported symptoms of TMD was 30.5% (n=86). In the final multivariate model, female older adults presented higher prevalence ratio (PR) for symptoms of TMD, presenting 62.8% (p=0.040) higher PR to at least mild symptoms of TMD when compared to older adult men. Number of teeth, need for dental prosthesis or other demographic variables were not associated with symptoms of TMD. CONCLUSION: The results demonstrated a prevalence of TMD symptoms in the seniors of approximately 30%, which was most associated with females. Despite its relevance in public health strategies focused on older adults, these findings should be interpreted with caution due to their observational and cross-sectional nature.

RESUMO JUSTIFICATIVA E OBJETIVOS: As disfunções temporomandibulares (DTM) são um grupo de condições caracterizadas por alteração dos movimentos e função da região orofacial e um dos maiores sintomas relatados é a dor. Como estas disfunções têm sido descritas de forma crescente entre diversas faixas etárias, o objetivo deste estudo foi avaliar a presença de sintomas de DTM e seus possíveis fatores associados em idosos de uma cidade do sul do Brasil. MÉTODOS: Estudo transversal de base domiciliar com amostra probabilística por conglomerado incluindo 282 idosos com idade ≥60 anos da cidade de Veranópolis/RS. Um exame clínico de saúde bucal e questionário estruturado foram aplicados. Sintomas de DTM foram avaliados pelo Índice Anamnésico de Fonseca (IAF) e categorizados em "Sem DTM" e "Com DTM", sendo que o último incluiu aqueles com sintomas compatíveis com DTM, moderada ou grave. Associações foram avaliadas pelos testes de Qui-quadrado ou Mann-Whitney por distribuição de frequências. Análises bi e multivariadas foram realizadas utilizando-se regressão de Poisson com variância robusta para verificar associações. RESULTADOS: A prevalência de idosos que relataram sintomas de DTM foi de 30,5% (n=86). No modelo multivariado final, idosas do sexo feminino apresentaram maior razão de prevalência (RP) para sintomas de DTM, apresentando 62,8% maior RP (p=0,040) de ter, pelo menos, sintomas leves de DTM quando comparados a idosos do sexo masculino. O número de dentes presentes, necessidade de prótese ou outras variáveis demográficas não estiveram associadas com a presença de sintomas de DTM. CONCLUSÃO: Os achados do presente estudo demonstraram prevalência de sintomas de DTM em idosos de aproximadamente 30%, com maior associação com o sexo feminino. Apesar de relevantes para delineamento de estratégias de saúde para idosos, os achados do presente estudo devem ser interpretados com cautela por sua natureza observacional e transversal.

Obesity is associated with lack of access to dental care and physical activity among older adults: a cross-sectional study / Obesidade está associada com falta de acesso a serviços odontológicos e atividade física em idosos: um estudo transversal

OBJECTIVE: This study evaluated the prevalence of obesity and associated factors among older adults. METHODS: This was a household-based cross-sectional study involving 282 individuals aged ≥ 60 years recruited in the city of Veranópolis, Brazil, using random probabilistic sampling. Participants underwent a clinical oral examination and completed a structured questionnaire. Obesitywas determined based on body mass index (BMI). Individuals were divided into two groups based on the presence (BMI ≥ 30 kg/m2) or absence of obesity (BMI < 30 kg/m2). Uni- and multivariate analyses were performed using Poisson regression with robust variance. RESULTS: The prevalence of obesity was 34% (n = 96). Each 1-year increase in age resulted in a 3.09% decrease in the likelihood of being classified as having obesity (prevalence ratio [PR] = 0.969; 95% confidence interval [95%CI] 0.949 ­ 0.989). Older adults that reported walking < 5 or ≥ 5 times per week were 39.65 and 37.20% less likely to be classified as obese. The PRs of obesity in former and non-smokers were 4.40 and 5 times higher, respectively, than in current smokers (p < 0.05). Older adults with no access to dental care were 51.72% (p = 0.013) more likely to present with obesity. CONCLUSIONS: There was a high prevalence of obesity among older adults. Obesity was associated with lower age, smoking status, no access to dental care, and a lack of physical activity

OBJETIVO: O presente estudo avaliou a prevalência de obesidade e fatores associados em idosos. METODOLOGIA: Um estudo transversal domiciliar, com amostragem probabilística, foi realizado com 282 indivíduos de idade ≥60 anos de Veranópolis, Brasil. Um exame clínico de saúde bucal foi realizado e um questionário estruturado foi aplicado. A obesidade foi determinada pelo Índice de Massa Corporal (IMC). Os indivíduos foram categorizados com obesidade (IMC ≥ 30kg/m2) e sem obesidade (IMC < 30kg/m2). Análises uni e multivariadas foram feitas por meio de regressão de Poisson com variância robusta. RESULTADOS: A prevalência de obesidade foi de 34% (n = 96). Cada ano de aumento na idade resultou em uma diminuição de 3,09% (razão de prevalência [RP] = 0,969; intervalo de confiança de 95% [IC95%] = 0,949 ­ 0,989) na RP de ser do grupo de obesos. Idosos que reportaram caminhar < cinco ou ≥ cinco vezes por semana apresentaram menor RP para obesidade, 39,65 e 37,20%, respectivamente. Ex-fumantes e não fumantes obtiveram, respectivamente, 4,40 e 5 vezes maior RP de serem do grupo de obesos quando comparados aos fumantes (p < 0,05). Idosos sem acesso a serviços odontológicos demonstraram 51,72% (p = 0,013) maior RP de serem do grupo com obesidade. CONCLUSÕES: Houve uma alta prevalência de obesidade em idosos, que foi associada com menor idade, estado de fumo e ausência de acesso ao dentista e atividade física.

Oral health-related quality of life and associated factors in the elderly: a population-based cross-sectional study / Qualidade de vida relacionada à saúde bucal e fatores associados em idosos: um estudo transversal com amostra representativa

Abstract This study aimed to evaluate the oral health-related quality of life (OHRQoL) and associated factors in the elderly. A cross-sectional study was conducted with 287 elderly of Cruz Alta, Brazil. The following variables were collected: age, sex, ethnicity, level of education, marital status, retirement, medical/dental history, smoking/alcohol exposure, oral hygiene habits, use and need of dental prosthesis, missing teeth, temporomandibular disorder symptoms (TMD), nutritional status, and halitosis. OHRQoL was assessed by Oral Health Impact Profile-14 (OHIP-14). The sample was categorized into low impact (sum scores ≤6) and high impact (sum scores ≥7). Associations were analyzed by Poisson regression with robust variation. Mean scores of OHIP-14 was 5.92±8.54. Divorced individuals and those who did not use dental floss presented 77% and 54%, respectively, higher prevalence ratio (PR) of having higher OHRQoL impact. Elderly that did not need dental prosthesis demonstrated a lower impact on OHRQoL (P<0.01). Elderly with TMD presented a higher PR of having higher OHRQoL impact (P<0.01). It was concluded that higher impact on OHRQoL was associated with marital status, non-users of dental floss and those with TMD. No need dental prosthesis were associated with lower impact on OHRQoL.

Resumo O estudo avaliou a qualidade de vida relacionada à saúde bucal (QVRSB) e fatores associados em idosos. Estudo transversal foi realizado em 287 idosos de Cruz Alta, Brasil. As seguintes variáveis foram coletadas: idade, sexo, etnia, nível educacional, estado civil, aposentadoria, histórico médico/odontológico, exposição ao fumo/álcool, hábitos de higiene oral, uso e necessidade de prótese, dentes ausentes, sintomas de desordem temporomandibular (DTM), estado nutricional e halitose. QVRSB foi avaliada pelo OHIP-14 (Perfil de Impacto de Saúde Bucal) e categorizado em baixo impacto (soma dos escores ≤6) e alto impacto (soma dos escores ≥7). Associações foram avaliadas por regressão de Poisson com variância robusta. A média OHIP-14 foi 5,92±8.54. Indivíduos divorciados e aqueles que reportaram não usar fio dental apresentaram 77% e 54%, respectivamente, maior razão de prevalência (RP) de terem maior impacto na QVRSB. Idosos que não necessitam próteses dentárias demonstraram menor impacto na QVRSB (P<0,01). Além disso, idosos com DTM apresentaram maior RP de terem maiores escores de OHIP-14 (P<0,01). Foi concluído que maiores impactos na QVRSB estão associados com estado civil, não uso de fio dental e DTM. Não necessitar de prótese dentária esteve associado com menores impactos na QVRSB.

Low concern rate with oral health and associated factors among older persons: a cross-sectional study / Baixas taxas de preocupação com a saúde bucal e fatores associados em idosos: um estudo transversal

OBJECTIVE: This study aimed to assess the prevalence of concern with oral health and associated factors among older adults. METHODS: Individuals aged >60 years were included from the cities Cruz Alta and Veranopolis, Brazil. Oral health examination and a structured questionnaire were applied in 569 individuals. The main outcome was concern with oral health (yes or no), which was determined by a validated questionnaire. Uni- and multivariate analyses were conducted by Poisson regression with robust variance to assess the association between outcome and independent variables. RESULTS: The prevalence of concern with oral health was 30.58% (n = 174). Non-white individuals presented significantly higher prevalence ratio (PR) of being concerned about their oral health (PR = 1.28; 95% confidence interval [CI] 1.01-1.62). Individuals with medium or high level of education, not retired and without any health problems presented higher PR of being concerned with their oral health when compared to their controls (p < 0.05). Moreover, those that reported toothbrushing frequency > 2 times/day (PR = 1.58; 95%CI 1.01 - 2.48) and non-edentulous (PR = 1.50; 95%CI 1.12 -2.01) also presented higher PR of being concern with their oral health. Older adults that were not concerned with tooth alignment (PR = 0.57; 95%CI 0.44 - 0.74) or tooth color (PR = 0.41; 95%CI 0.31 - 0.54) demonstrated lower concern with their oral health. CONCLUSION: Prevalence of concern with oral health among the older adults was low and associated with non-white individuals, medium and high level of education, individuals not retired, absence of health problems, higher toothbrushing frequency, mild temporomandibular disorder (TMD) and non-edentulism. Additionally, concern with esthetical aspects may be related with this outcome.

OBJETIVO: Esse estudo objetivou verificar a prevalência de preocupação com a saúde bucal e fatores associados em idosos. METODOLOGIA: Idosos com idade ≥60 anos foram incluídos das cidades de Cruz Alta e Veranópolis, Brasil. Exame de saúde bucal e um questionário estruturado foram aplicados em 569 indivíduos. O desfecho primário foi preocupação com saúde bucal (sim ou não), a qual foi determinada por um questionário validado. Análises uni- e multivariadas foram realizadas por meio de regressão de Poisson com variância robusta para verificar a associação entre o desfecho e as variáveis independentes. RESULTADOS: A prevalência de preocupação com a saúde bucal foi de 30,58% (n = 174). Indivíduos não brancos apresentaram razão de prevalência (RP) significativamente maior de serem preocupados com a sua saúde bucal (RP = 1,28 ­ intervalo de confiança [IC] de 95% 1,01 ­ 1,62). Indivíduos com nível educacional médio ou alto, não aposentados e sem qualquer problema de saúde apresentaram maior RP de serem preocupados com sua saúde bucal quando comparados com seus controles (p < 0,05). Além disso, idosos que reportaram escovar os dentes ≥ 2 vezes/dia (RP = 1,58; IC95% 1,01 ­ 2,48) e não edêntulos (RP = 1,50; IC95% 1,12 ­ 2,01) também apresentaram maior RP de serem preocupados com sua saúde bucal. Idosos não preocupados com alinhamento dentário (RP = 0,57; IC95% 0,44 ­ 0,74) ou com a cor dos dentes (RP = 0,41; IC95% 0,31 ­ 0,54) demonstraram menor preocupação com a saúde bucal. CONCLUSÃO: Prevalência de preocupação com a saúde bucal em idosos foi baixa e associada com indivíduos não brancos, com nível educacional médio ou alto, indivíduos não aposentados, ausência de problemas de saúde, alta frequência de escovação, desordem temporomandibular (DTM) leve e não edêntulos. Além disso, preocupação com aspectos estéticos pode estar relacionada com isso.

Brazilian dentistry research productivity: state level socioeconomic, educational and structural factors

Aim: To explore socioeconomic, educational and research factors associated with dental research productivity at the state level in Brazil. Methods: The authors used the Scopus database to identify dental articles published from 2006 to 2016 associated with Brazilian universities at the state level. Several social, economic, educational and research structure variables were obtained from the census and National Research Council to predict the rate of articles per 100 thousand inhabitants among the 27 Brazilian states. Rates were fitted in linear weighted least-squared regression with stepwise technique. Twenty-two variables were grouped in six blocks (social, economic, general education, dental education, research workforce and structure). Results: A total of 21189 articles were published, and the state of São Paulo accounted for 46%, followed by Rio Grande do Sul with 9.4%; four states did not publish any articles. There were an average (± standard deviation) of 2.6 (±1.98) published articles per 100 researchers and 13.4 (±9.6) articles per 100 thousand inhabitants. Research structure and workforce explained 92.4% and 87.2% of state variability, respectively, while the final model explained 94.5%. One extra PhD and one extra undergraduate researcher per 100 thousand inhabitants were associated with 11.3 more and 3.5 fewer articles, respectively, while every 10 points (range 0-100) on the Human Development Index (Education Component) was associated with 3.3 more articles. Conclusion: State scientific output has several associated factors, but research workforce and general education variables seem to be good predictors. Large disparities among state research outputs have been described and must be addressed by research and development policies

Dental Care and the COVID-19 Pandemic: The Precautionary Principle and the Best Available Evidence

Abstract The precautionary principle is part of evidence-based healthcare and is used both preventively and therapeutically when there is no available evidence about how to manage problems/diseases/conditions that are especially life-threatening. However, since it is not always based in the most qualified evidence, it is frequently questioned. The emergence of a highly contagious disease, with increased levels of morbimortality, an acute respiratory syndrome, the so called Coronavirus Disease 2019 (COVID-19), led health professionals to look for the best alternatives to save lives. In this sense, the precautionary principle was evocated. The aim of this paper is to make a reflection about the precautionary principle, the dental profession and COVID-19. It is important to have in mind that in such a disease, guidelines, protocols and approaches can change very fast, since a continuous evaluation of all policies is mandatory. During the pandemic, elective procedures may be restricted, but international organizations removed the recommendation to postpone elective procedures. Clinicians are advised to be updated about their local current policies. On the other hand, there are cases in which in-office dental care is unavoidable, such as individuals with pain, spontaneous bleeding and dental trauma. Biosafety is upmost importance when seeking patients during pandemic. In this sense, it was concluded that precautionary principle should be, therefore, used. However, caution needs to be taken and continuous surveillance necessary.

Concern with dental appearance and associated factors among the elderly of two southern Brazilian cities: a cross-sectional study

Aim: This study aimed to evaluate the prevalence of concern with dental appearance (DA) and associated factors among the elderly of two southern Brazilian cities. Methods: A cross-sectional study was conducted in the cities of Cruz Alta and Veranópolis, Brazil. Oral health examination and a structured questionnaire were applied. Questions from the PCATool-SB Brasil tool and the Questionnaire about Teeth Appearance, both validated to Brazilian samples, were used. The collected independent variables were: sex, age, ethnicity, education level, marital status, retirement, health problem, use of medication, smoking exposure, alcohol exposure, access to the dentist, toothbrushing frequency, use of dental floss, edentulism, use of and need for dental prosthesis. Concern with DA was dichotomized into yes/no. Associations between dependent and independent variables were assessed by Chi-square or Mann-Whitney tests. Moreover, uni- and multivariate analyses were conducted by Poisson regression with robust variance. Level of significance was established as p<0.05. Results: The prevalence of concern with DA was 18.8% (n=107). The prevalence ratio (PR) of concern with DA decreased 5.8% for each year increase (PR:0.942; 95% confidence interval [95%CI]:0.911­0.973). Elderly without access to the dentist in the last 12 months presented 62.5% (p=0.006) higher PR of concern with DA when compared to those with access to dental care. Dentate elderly showed 219% higher PR for concern with DA (PR:2.197; 95%CI:1.364­3.539) in comparison to edentulous individuals. Conclusion: Prevalence of concern with DA was low and associated with demographics, access to dental care and edentulism

Effects of low molecular weight heparin on alveolar bone loss in wistar rats

Abstract This study aimed to assess the effects of low molecular weight heparin (LMWH) on alveolar bone loss (ABL), blood count, and counting of megakaryocytes and adipocytes in male Wistar rats. Forty male 60-day Wistar rats were randomly divided into four groups: Control (C), Periodontal Disease (PD), Heparin (Hp) and Heparin + Periodontal Disease (Hp+PD). LMWH was applied for 60 days at doses of 1 ml/kg/day. Blood samples were collected at baseline, 30 and 60. On day-49, PD and Hp+PD groups were subjected to ligature-induced periodontitis around second upper right molar. The left side was assessed as spontaneous alveolar bone loss. Mean ABL in the side with ligature showed significantly different between C (0.35±0.07 mm) and Hp+DP (0.49±0.09 mm) groups (p<0.001), between PD (0.55±0.11 mm) and Hp (0.32±0.06 mm) groups (p<0.001) and between Hp and Hp+DP groups (p<0.001). No significant differences were found among groups for ABL in the side without ligature. Animal weight, food intake, and water consumption showed no statistically significant difference among groups. Megakaryocytes and adipocytes were counted using optical microscopy and no statistically significant differences were found. Within-groups, there were an increase and a decrease, respectively, in the counting of lymphocytes (p=0.005 for C and p=0.009 for Hp+PD groups only) and leukocytes (p=0.003 for C, p=0.001 for PD, p=0.002 for Hp, and p<0.001 for Hp+PD groups). There was no decrease in the number of platelets in the three collection periods. LMWH was not able to affect ABL, but it may change the blood counting, especially increasing lymphocytes.

Resumo O presente estudo objetivou verificar o efeito da heparina de baixo peso molecular (HBPM) sob a perda óssea alveolar (POA), contagem de células sanguíneas, megacariócitos e adipócitos em ratos Wistar machos. Quarenta ratos Wistar de 60 dias foram randomicamente divididos em quatro grupo: Controle (C), Doença Periodontal (DP), Heparina (Hp) e Heparina + Doença Periodontal (Hp+DP). HBPM foi aplicada durante 60 dias em doses de 1 mL/kg/dia. Coletas sanguíneas foram realizadas nos dias 0, 30 e 60. No dia 49, os grupos DP e Hp+DP receberam indução de doença periodontal por ligadura ao redor do segundo molar superior direito. No lado esquerdo, verificou-se perda óssea alveolar espontânea. A média de POA no lado com ligadura mostrou-se estatisticamente diferente entre os grupos C (0,35±0,07 mm) e Hp+PD (0,49±0,09 mm) (p<0,001), entre os grupos DP (0,55±0,11 mm) e Hp (0,32±0,06 mm) (p<0,001) e entre os grupos Hp e Hp+DP (p<0,001). Nenhuma diferente significativa foi observada entre os grupos no lado sem ligadura. Peso dos animais, consumo de ração e ingestão de água não mostraram diferenças significativas entre os grupos. Megacariócitos e adipócitos foram contados por microscopia óptica e nenhuma diferença significativa foi encontrada. Dentro dos grupos, houve um aumento e uma diminuição, respectivamente, na contagem de linfócitos (p=0,005 no grupo C e p=0,009 no grupo Hp+DP somente) e leucócitos (p=0,003 no grupo C, p=0.001 no grupo DP e p=0,002 no grupo Hp e Hp+DP). Não houve diminuição no número de plaquetas nos três períodos de coleta. HBPM não foi capaz de modificar a POA, porém modificou a contagem de células sanguíneas, especialmente aumentando o número de linfócitos.

Fontes de estresse, bem-estar psicológico e saúde entre estudantes de Odontologia: uma comparação entre fases pré-clínica e clínica e entre os sexos / Sources of stress, psychological well-being and health among dental students: a comparison between preclinical and clinical phases and between sexes

O objetivo do estudo foi avaliar bem-estar psicológico, saúde geral e fontes de estresse de estudantes de Odontologia de quatro cursos, comparando as fases pré-clínica e clínica e os sexos. Três instrumentos foram aplicados: Dental Environment Stress (DES), Psychological General Well-Being Index (PGWB) e Health Survey (SF-36), respondidos por 203 estudantes, sendo 75 (37%) em fase pré-clínica e 128 (63%) em clínica. Desses, 59 (29%) eram homens e 144 (71%) mulheres. As comparações foram realizadas pelo teste de Mann-Whitney, adotando um nível de significância de 5%. Nos domínios analisados pelo DES (performance acadêmica; dificuldades e inseguranças sobre o futuro profissional; responsabilidade com pacientes; fatores pessoais e institucionais; relações interpessoais), estudantes em fase pré-clínica demonstraram escores significativamente menores quando comparados a estudantes em fase clínica. No escore total de PGWB e em dois domínios (ansiedade e saúde geral), observou-se também escores menores em estudantes em fase pré-clínica. Quatro domínios do SF-36 (dor corporal, funcionamento físico, funcionamento social e papel físico), apresentaram significativa melhor saúde geral dos estudantes em fase pré-clínica. Entre os sexos, dois domínios do DES (performance acadêmica, dificuldade e insegurança sobre o futuro profissional) mostraram menores fatores estressores para o sexo masculino. O PGWB demonstrou diferença significativa em quatro domínios (estado deprimido; autocontrole; saúde geral; vitalidade), com melhor bem-estar psicológico para homens. O sexo masculino apresentou melhor vitalidade no domínio do SF-36. Concluiu-se que estudantes em fase pré-clínica e do sexo masculino demonstraram menores fontes de estresse, melhor bem-estar psicológico e percepção de saúde geral (AU).

The aim of this study was to evaluate psychological well-being, overall health, and sources of stress among dental students from four Doctor of Dental Surgery (DDS) programs, comparing the preclinical and clinical phases and sexes. Three instruments were applied: Dental Environment Stress (DES), Psychological General Well-Being Index (PGWB) and Health Survey (SF-36), answered by 203 students, with 75 (37%) in the preclinical phase and 128 (63%) in the clinical one. Among them, 59 were male (29%) and 144 were female (71%). Comparisons were performed using the Mann-Whitney test, adopting a significance level of 5%. In the domains analyzed using DES (academic performance, difficulties and insecurities about their professional future, responsibilities with patients, personal and institutional factors, interpersonal relationships), preclinical students showed significantly lower scores than students enrolled in the clinical phases. For PGWB total score and in two domains (anxiety and general health), lower scores were also observed in preclinical students. Four domains of SF-36 (bodily pain, physical functioning, social functioning and role-physical) showed significantly better overall health for preclinical students. Among the sexes, two DES domains (academic performance and difficulties and insecurities about their professional future) showed lower stressors for males. PGWB showed a significant difference in four domains (depressed mood, self-control, general health and vitality), with better psychological well-being for males. Males showed better vitality in the SF-36 domain. Concluding, preclinical and male students showed lower sources of stress, better psychological well-being and better perception of their overall health (AU).

Tooth loss and associated factors in adolescents ­ impact of extractions for orthodontic reason

Aim: To investigate tooth loss and its determinants in adolescents, considering the effect of extractions due to orthodontics reasons. Methods: This cross-sectional study was performed in students from public and private schools aged 15-19 years old from Passo Fundo, Brazil. The proportional randomly chosen sample included 736 adolescents. Clinical examinations and interviews were performed. Associations between prevalence of tooth loss and exposure variables studied were analysed by Poisson Regression with uni- and multivariate robust variance in two models. One model comprised students who had experienced tooth loss without orthodontic reasons and the other with all of the subjects presenting tooth loss. Results: Prevalence of tooth loss was 21.1% (mean of 0.42). Higher chances for tooth loss were found in the following features: non-whites (PR=1.72; CI95%:1.15-2.60), poorly schooling mothers (PR=2.2; CI95%:0.96-5.02), from public schools (PR=4.16; CI95%:0.98-17.59), smokers (PR=1.91; CI95%:1.15-3.17). Conclusion: Demographic, socioeconomic and behavioural conditions were strongly associated with tooth loss. These associations were more evident when extractions for orthodontic reasons were not included in the analytical models